Types of Breast Cancer
Non Infiltrating type
called in situ) breast cancer. This does NOT metastasize
but breast recurrence is a problem.
There are two types:
1. Lobular carcinoma in situ
is usually an incidental biopsy diagnosis. It is an 8 to 10
times risk factor (26) giving about a 1% per year risk for
invasive carcinoma in the same or opposite breast. Treatment
may be either observation or bilateral mastectomies.
2. Intraductal carcinoma is
being diagnosed with increasing frequency due to mammography.
The risk for subsequent invasive cancer is about 1% per year in
the opposite breast so the contralateral risk approaches that
for lobular carcinoma in situ. Recurrence in the same
breast varies by type.
There are following subtypes,
based on morphologic criteria
particularly when of high grade and usually the comedo type,
can travel extensively but undetected through the breast.
Because of this, there is a risk for the subsequent development
of invasive cancer in the breast after the in situ
cancer is excised. For this reason, radiotherapy or mastectomy
may be indicated after excision of intraductal
carcinoma.Eventually, intraductal cancer can become invasive.
The behavior of low grade ductal in situ and lobular
carcinoma in situ is quite similar.
Invasive breast cancer:
Increasing age is the chief risk
May be associated with skin
fixation, dimpling, or nipple retraction.
Common Types of invasive
Less common types (%
occurrence). In pure form, these tend to have a relatively good
Mucoid or colloid breast
Tubular breast cancer-1.2%
Adenoid cystic- breast
Cribriform breast cancer-0.3%
Papillary breast cancer
Squamous breast cancer
Apocrine breast cancer
Hormone Receptor positive
Breast Cancer - Up to 70% or so of breast cancer is either
estrogen or progesterone receptor positive. Identifying a
cancer, as hormone receptor positive is important to determine
hormonal treatment is an option.
Stages of Breast Cancer -
It is important to know the exact stage of the cancer because
treatment and prognosis of Breast Cancer largely depends on the
stage of the cancer.
Stage 0 - Cancer within the
duct or the lobule, without any invasion of surrounding tissue.
Stage I- disease for
invasive breast cancer means that the cancer is limited to the
breast itself. It does not involve lymph nodes in the armpit
and has not spread to other areas in the body. Stage I disease
is still a life-threatening illness potentially, and for about
20% of the individuals, there is a long-term risk of recurrence
Stage II- cancer that
involves the breast and the regional lymph nodes, the long-term
survival is not as good. It's probably in the range of 40 to
60% long-term survival from the disease.
Stage III- disease is
larger tumors that involve greater numbers of lymph nodes.
Stage IV- (Metastatic
disease) in which cancer has spread beyond the breast and
immediately adjacent lymph nodes. 5-year survival is between