of pleural mesothelioma
of exposure to asbestos.
chest - Chest radiographs reveal a variable amount of fluid,
with pleural thickening or pleural nodules, often several
centimeters in diameter, imposing a scalloped appearance.
Mediastinum shift might be visible.
scan, MRI can detect the extent of the disease
reveals malignant cells in up to 30% cases and high content
of hyaluronic acid.
and ECG may reveal cardiac abnormality and pericardial
or thoracotomy with biopsy is needed to confirm the
of peritoneal mesothelioma:
of mesothelioma is often very difficult due to its diffuse mass.
Treatment modalities include-
combination of Radiotherapy using Iodine-125 or Iridium-192
implants and surgery
chemotherapy- Chemotherapy can be given either intravenously
or intracavitary (chemotherapeutic agent put inside pleura
or peritoneum). Doxorubicin , 5-azacytidine, cisplatin,
mitomycin, 5-FU, methyl CCNU, and actinomycin
all have been used in different combinations.
therapy - Human recombinant IFN-a was first shown to
potentiate the effect of chemotherapy. Interleukine-2 has
also some beneficial effect in patients with mesothelioma.
developments - Adding pemetrexed (Alimta)
to cisplatin improved survival for patients with malignant
pleural mesothelioma, according to the results of a
randomized phase III trial published in the July 15 2003,
issue of the Journal of Clinical Oncology.